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  Ubiquitin ligase EBAX-1/ZSWIM8 is required for transgenerational inheritance of a predatory morph by destabilizing clustered microRNAs in a developmentally plastic nematode

Quiobe, S., Kalirad, A., Witte, H., Roeseler, W., Roedelsperger, C., & Sommer, R. (2024). Ubiquitin ligase EBAX-1/ZSWIM8 is required for transgenerational inheritance of a predatory morph by destabilizing clustered microRNAs in a developmentally plastic nematode. In 2024 European Worm Meeting.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-7583-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-7585-7
Genre: Meeting Abstract

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https://virtual.oxfordabstracts.com/#/event/5020/submission/93 (Abstract)
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 Creators:
Quiobe, SP1, Author                 
Kalirad, A1, Author                 
Witte, H1, Author                 
Roeseler, W1, Author                 
Roedelsperger, C1, 2, Author                 
Sommer, R1, Author                 
Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Biology Tübingen, Max Planck Society, ou_3371685              
2Evolutionary Genomics and Bioinformatics Group, Department Integrative Evolutionary Biology, Max Planck Institute for Biology Tübingen, Max Planck Society, ou_3507717              

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 Abstract: Environmental influences on traits and associated transgenerational epigenetic inheritance (TEI) have widespread implications but remain controversial and underlying mechanisms little understood. Fundamental insight could be obtained by integrating experiments that visualize plasticity in response to environmental stimuli with experimental evolution. We used long-term environmental induction on alternative diets in Pristionchus pacificus nematodes that exhibit natural mouth-form plasticity including a predatory morph. Propagation of 110 isogenic lines for 101 generations and associated food-reversal experiments revealed dietary induction of the predatory morph and its subsequent TEI. This memory requires at least five generations of induction, which is phenomenologically different from previous examples of TEI. Coupling dietary induction with mutagenesis identified the ubiquitin ligase EBAX-1. Ppa-ebax-1 mutants responded to dietary induction but showed no memory. We found Ppa-EBAX-1 destabilizes the microRNAs family miR-2235/miR-35. Deletion of a cluster of 44 identical copies of miR-2235 resulted in precocious and extended TEI of the predatory morph.

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 Dates: 2024-07
 Publication Status: Published online
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Title: 2024 European Worm Meeting
Place of Event: Utrecht, The Netherlands
Start-/End Date: 2024-07-01 - 2024-07-03

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Title: 2024 European Worm Meeting
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 93 Start / End Page: - Identifier: -