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  Minimal-invasive 3D laser printing of microimplants in organismo

Afting, C., Mainik, P., Vazquez-Martel, C., Abele, T., Kaul, V., Kale, G., et al. (2024). Minimal-invasive 3D laser printing of microimplants in organismo. Advanced Science, 11(30): 2401110, pp. 1-11. doi:10.1002/advs.202401110.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-7DB1-D Version Permalink: https://hdl.handle.net/21.11116/0000-000F-C7E9-A
Genre: Journal Article

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 Creators:
Afting, Cassian, Author
Mainik, Philipp, Author
Vazquez-Martel, Clara, Author
Abele, Tobias1, Author           
Kaul, Verena, Author
Kale, Girish, Author
Göpfrich, Kerstin1, Author           
Lemke, Steffen, Author
Blasco, Eva, Author
Wittbrodt, Joachim, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: 3D laser printing; Drosophila melanogaster; Oryzias latipes; additive manufacturing; bioengineering; microimplants; two‐photon lithography
 Abstract: Multi-photon 3D laser printing has gathered much attention in recent years as a means of manufacturing biocompatible scaffolds that can modify and guide cellular behavior in vitro. However, in vivo tissue engineering efforts have been limited so far to the implantation of beforehand 3D printed biocompatible scaffolds and in vivo bioprinting of tissue constructs from bioinks containing cells, biomolecules, and printable hydrogel formulations. Thus, a comprehensive 3D laser printing platform for in vivo and in situ manufacturing of microimplants raised from synthetic polymer-based inks is currently missing. Here, a platform for minimal-invasive manufacturing of microimplants directly in the organism is presented by one-photon photopolymerization and multi-photon 3D laser printing. Employing a commercially available elastomeric ink giving rise to biocompatible synthetic polymer-based microimplants, first applicational examples of biological responses to in situ printed microimplants are demonstrated in the teleost fish Oryzias latipes and in embryos of the fruit fly Drosophila melanogaster. This provides a framework for future studies addressing the suitability of inks for in vivo 3D manufacturing. The platform bears great potential for the direct engineering of the intricate microarchitectures in a variety of tissues in model organisms and beyond.

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Language(s): eng - English
 Dates: 2024-05-102024-01-302024-06-122024-08-14
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: https://pubmed.ncbi.nlm.nih.gov/38864352/
DOI: 10.1002/advs.202401110
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Title: Advanced Science
  Other : Adv. Sci.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 11 (30) Sequence Number: 2401110 Start / End Page: 1 - 11 Identifier: ISSN: 2198-3844
CoNE: https://pure.mpg.de/cone/journals/resource/2198-3844