English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Contributions of short- and long-range white matter tracts in dynamic compensation with aging

Chakraborty, P., Saha, S., Deco, G., Banerjee, A., & Roy, D. (2025). Contributions of short- and long-range white matter tracts in dynamic compensation with aging. Cerebral Cortex, 35(2): bhae496. doi:10.1093/cercor/bhae496.

Item is

Files

hide Files
:
Chakraborty_Saha_pre.pdf (Preprint), 4MB
Name:
Chakraborty_Saha_pre.pdf
Description:
-
OA-Status:
Green
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

hide
Locator:
https://doi.org/10.1093/cercor/bhae496 (Publisher version)
Description:
-
OA-Status:
Closed Access
Description:
-
OA-Status:
Green

Creators

hide
 Creators:
Chakraborty, Priyanka1, 2, Author
Saha, Suman1, 3, Author
Deco, Gustavo4, 5, 6, 7, Author           
Banerjee, Arpan1, Author
Roy, Dipanjan8, Author
Affiliations:
1Cognitive Brain Dynamics Lab, National Brain Research Centre, Haryana, India, ou_persistent22              
2Department of Mathematics, Rampurhat College, India, ou_persistent22              
3School of Electronics Engineering, Vellore Institute of Technology, India, ou_persistent22              
4Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
8School of Artificial Intelligence and Data Science (AIDE), Indian Institute of Technology Jodhpur, India, ou_persistent22              

Content

hide
Free keywords: Aging; Compensation; Metastability; Subcommunity; White matter fiber tracts
 Abstract: Optimal brain function is shaped by a combination of global information integration, facilitated by long-range connections, and local processing, which relies on short-range connections and underlying biological factors. With aging, anatomical connectivity undergoes significant deterioration, which affects the brain's overall function. Despite the structural loss, previous research has shown that normative patterns of functions remain intact across the lifespan, defined as the compensatory mechanism of the aging brain. However, the crucial components in guiding the compensatory preservation of the dynamical complexity and the underlying mechanisms remain uncovered. Moreover, it remains largely unknown how the brain readjusts its biological parameters to maintain optimal brain dynamics with age; in this work, we provide a parsimonious mechanism using a whole-brain generative model to uncover the role of sub-communities comprised of short-range and long-range connectivity in driving the dynamic compensation process in the aging brain. We utilize two neuroimaging datasets to demonstrate how short- and long-range white matter tracts affect compensatory mechanisms. We unveil their modulation of intrinsic global scaling parameters, such as global coupling strength and conduction delay, via a personalized large-scale brain model. Our key finding suggests that short-range tracts predominantly amplify global coupling strength with age, potentially representing an epiphenomenon of the compensatory mechanism. This mechanistically explains the significance of short-range connections in compensating for the major loss of long-range connections during aging. This insight could help identify alternative avenues to address aging-related diseases where long-range connections are significantly deteriorated.

Details

hide
Language(s): eng - English
 Dates: 2024-10-262024-08-142024-12-132025-01-132025-02-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhae496
PMID: 39807971
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

hide
Title: Cerebral Cortex
  Abbreviation : 1047-3211
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 : Oxford University Press
Pages: - Volume / Issue: 35 (2) Sequence Number: bhae496 Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/1047-3211