English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Convergent functional effects of antidepressants in major depressive disorder: A neuroimaging meta-analysis

Saberi, A., Ebneabbasi, A., Rahimi, S., Sarebannejad, S., Sen, Z. D., Graf, H., et al. (2025). Convergent functional effects of antidepressants in major depressive disorder: A neuroimaging meta-analysis. Molecular Psychiatry, 30(2), 736-751. doi:10.1038/s41380-024-02780-6.

Item is

Files

hide Files
:
Saberi_2024.pdf (Publisher version), 3MB
Name:
Saberi_2024.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
:
Saberi_2024_Suppl.pdf (Supplementary material), 3MB
Name:
Saberi_2024_Suppl.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

hide
Description:
-
OA-Status:
Green

Creators

hide
 Creators:
Saberi, Amin1, 2, 3, Author                 
Ebneabbasi, Amir4, 5, Author
Rahimi, Sama1, 2, 6, Author
Sarebannejad, Sara7, Author
Sen, Zumrut Duygu8, 9, 10, 11, Author
Graf, Heiko12, Author
Walter, Martin8, 9, 10, 11, 13, Author
Sorg, Christian14, 15, 16, Author
Camilleri, Julia A.1, 2, Author
Laird, Angela R.17, Author
Fox, Peter T.18, Author
Valk, Sofie L.1, 2, 3, Author                 
Eickhoff, Simon B.1, 2, Author
Tahmasian, Masoud1, 2, 19, Author
Affiliations:
1Institute of Neuroscience and Medicine (INM-7), Brain and Behavior, Research Center Jülich, Germany, ou_persistent22              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
3Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
4Department of Clinical Neuroscience, University of Cambridge, United Kingdom, ou_persistent22              
5Cambridge University Hospitals NHS Trust, United Kingdom, ou_persistent22              
6Neuroscience Center, Goethe University, Frankfurt, Germany, ou_persistent22              
7Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
8Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Germany, ou_persistent22              
9Clinical Affective Neuroimaging Laboratory (CANLAB), Otto von Guericke University Magdeburg, Germany, ou_persistent22              
10Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
11German Center for Mental Health (DZPG), Jena, Germany, ou_persistent22              
12Department of Psychiatry and Psychotherapy, Ulm University, Germany, ou_persistent22              
13Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              
14Neuroimaging Center (TUM-NIC), TU Munich, Germany, ou_persistent22              
15Department of Neuroradiology, TU Munich, Germany, ou_persistent22              
16Department of Psychiatry and Psychotherapy, TU Munich, Germany, ou_persistent22              
17Department of Physics, Florida International University, Miami, FL, USA, ou_persistent22              
18Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA, ou_persistent22              
19Department of Nuclear Medicine, University of Cologne, Germany, ou_persistent22              

Content

hide
Free keywords: Depression; Neuroscience
 Abstract: Background: Neuroimaging studies have provided valuable insights into the macroscale impacts of antidepressants on brain functions in patients with major depressive disorder. However, the findings of individual studies are inconsistent. Here, we aimed to provide a quantitative synthesis of the literature to identify convergence of the reported findings at both regional and network levels and to examine their associations with neurotransmitter systems.

Methods: Through a comprehensive search in PubMed and Scopus databases, we reviewed 5258 abstracts and identified 36 eligible functional neuroimaging studies on antidepressant effects in major depressive disorder. Activation likelihood estimation was used to investigate regional convergence of the reported foci of antidepressant effects, followed by functional decoding and connectivity mapping of the convergent clusters. Additionally, utilizing group-averaged data from the Human Connectome Project, we assessed convergent resting-state functional connectivity patterns of the reported foci. Next, we compared the convergent circuit with the circuits targeted by transcranial magnetic stimulation therapy. Last, we studied the association of regional and network-level convergence maps with selected neurotransmitter receptors/transporters maps.

Results: No regional convergence was found across foci of treatment-associated alterations in functional imaging. Subgroup analysis in the Treated > Untreated contrast revealed a convergent cluster in the left dorsolateral prefrontal cortex, which was associated with working memory and attention behavioral domains. Moreover, we found network-level convergence of the treatment-associated alterations in a circuit more prominent in the frontoparietal areas. This circuit was co-aligned with circuits targeted by "anti-subgenual" and "Beam F3" transcranial magnetic stimulation therapy. We observed no significant correlations between our meta-analytic findings with the maps of neurotransmitter receptors/transporters.

Conclusion: Our findings highlight the importance of the frontoparietal network and the left dorsolateral prefrontal cortex in the therapeutic effects of antidepressants, which may relate to their role in improving executive functions and emotional processing.

Details

hide
Language(s): eng - English
 Dates: 2024-09-272023-11-212024-10-012024-10-152025-02
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41380-024-02780-6
Other: epub 2024
PMID: 39406999
 Degree: -

Event

show

Legal Case

show

Project information

hide
Project name : -
Grant ID : InterLabs-0015
Funding program : -
Funding organization : Helmholtz Association
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : -
Funding program : -
Funding organization : Canada First Research Excellence Fund (CFREF)
Project name : -
Grant ID : EI 816/21-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : R01-MH074457
Funding program : -
Funding organization : National Institute of Mental Health (NIMH)
Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union

Source 1

hide
Title: Molecular Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Houndmills, Hampshire, UK : Stockton Press
Pages: - Volume / Issue: 30 (2) Sequence Number: - Start / End Page: 736 - 751 Identifier: ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131