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  Homology Search By HMM-HMM Comparison Detects More Than Three Times As Many Remote Homologs as PSIBLAST or HMMER

Soeding, J., & Lupas, A. (2004). Homology Search By HMM-HMM Comparison Detects More Than Three Times As Many Remote Homologs as PSIBLAST or HMMER. In 1st Structural Bioinformatics Meeting at ISMB/ECCB2004 (pp. 21-22).

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Item Permalink: https://hdl.handle.net/21.11116/0000-0010-3E16-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0010-3E1E-9
Genre: Meeting Abstract

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http://www.weizmann.ac.il/3dsig/2004/3dsigbook.pdf (Abstract)
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 Creators:
Soeding, J1, Author                 
Lupas, AN1, Author                 
Affiliations:
1Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375791              

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 Abstract: We developed a homology search method based on pairwise comparison of profile HMMs. In an all-against-all benchmark (3691 SCOP 1.63 domains, < 20% sequence identity) the method detects 3-5 times more homologs than PSIBLAST or HMMER and between 25% and 100% more than profile-profile comparison tools COMPASS and PROF_SIM.

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 Dates: 2004-07
 Publication Status: Published online
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Title: 1st Structural Bioinformatics Meeting at ISMB/ECCB 2004
Place of Event: Glasgow, UK
Start-/End Date: 2004-07-29 - 2004-07-30

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Title: 1st Structural Bioinformatics Meeting at ISMB/ECCB2004
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 41 Start / End Page: 21 - 22 Identifier: -