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  The Circulating Proteome-Technological Developments, Current Challenges, and Future Trends

Geyer, P. E., Hornburg, D., Pernemalm, M., Hauck, S. M., Palaniappan, K. K., Albrecht, V., et al. (2024). The Circulating Proteome-Technological Developments, Current Challenges, and Future Trends. Journal of Proteome Research, 23(12), 5279-5295. doi:10.1021/acs.jproteome.4c00586.

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 Urheber:
Geyer, Philipp E.1, Autor           
Hornburg, Daniel2, Autor
Pernemalm, Maria2, Autor
Hauck, Stefanie M.2, Autor
Palaniappan, Krishnan K.2, Autor
Albrecht, Vincent1, 3, Autor           
Dagley, Laura F.2, Autor
Moritz, Robert L.2, Autor
Yu, Xiaobo2, Autor
Edfors, Fredrik2, Autor
Vandenbrouck, Yves2, Autor
Mueller-Reif, Johannes B.1, Autor           
Sun, Zhi2, Autor
Brun, Virginie2, Autor
Ahadi, Sara2, Autor
Omenn, Gilbert S.2, Autor
Deutsch, Eric W.2, Autor
Schwenk, Jochen M.2, Autor
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              
3IMPRS-ML: Martinsried, Max Planck Institute of Biochemistry, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_3531125              

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Schlagwörter: HUMAN PLASMA PROTEOME; BIOMARKER DISCOVERY; MASS-SPECTROMETRY; PROTEOGENOMIC CHARACTERIZATION; SERUM-PROTEINS; GLYCOSYLATION; GENETICS; HEALTH; ASSAY; ASSOCIATIONSBiochemistry & Molecular Biology; biomarker discovery; blood; plasma; serum; PTM; extracellular vesicle; microsampling; affinity; mass spectrometry; PeptideAtlas;
 Zusammenfassung: Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest in using these novel methods for studying the circulating proteome, as blood offers an accessible window into human health. However, every methodological innovation and analytical progress calls for reassessing our existing approaches and routines to ensure that the new data will add value to the greater biomedical research community and avoid previous errors. As representatives of HUPO's Human Plasma Proteome Project (HPPP), we present our 2024 survey of the current progress in our community, including the latest build of the Human Plasma Proteome PeptideAtlas that now comprises 4608 proteins detected in 113 data sets. We then discuss the updates of established proteomics methods, emerging technologies, and investigations of proteoforms, protein networks, extracellualr vesicles, circulating antibodies and microsamples. Finally, we provide a prospective view of using the current and emerging proteomics tools in studies of circulating proteins.

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Sprache(n): eng - English
 Datum: 2024-10-31
 Publikationsstatus: Erschienen
 Seiten: 17
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 001372083100001
DOI: 10.1021/acs.jproteome.4c00586
 Art des Abschluß: -

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Titel: Journal of Proteome Research
  Andere : J. Proteome Res.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : American Chemical Society
Seiten: - Band / Heft: 23 (12) Artikelnummer: - Start- / Endseite: 5279 - 5295 Identifikator: ISSN: 1535-3893
CoNE: https://pure.mpg.de/cone/journals/resource/111019664290000