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  A predatory fungus detects prey pheromones via G-protein-coupled receptors

Hsueh, Y.-P. (2024). A predatory fungus detects prey pheromones via G-protein-coupled receptors. Talk presented at Kiel Conference on Molecular Biology of Fungi 2024. Kiel, Germany. 2024-09-11 - 2024-09-13.

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Hsueh, Y-P1, Author                 
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1Department Complex Biological Interactions, Max Planck Institute for Biology Tübingen, Max Planck Society, ou_3603773              

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 Abstract: The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys oligospora and other nematode-trapping fungi develop dedicated structures for nematode capture when exposed to nematode-derived cues, including a conserved family of pheromones, the ascarosides. A. oligospora senses ascarosides via conserved MAPK and cAMP–PKA pathways; however, the upstream receptors remain unknown. Here, using genomic, transcriptomic and functional analyses, we identified two families of G protein-coupled receptors (GPCRs) involved in sensing distinct nematode-derived cues. GPCRs homologous to yeast glucose receptors are required for ascaroside sensing, whereas Pth11-like GPCRs contribute to ascaroside-independent nematode sensing. Both GPCR classes activate conserved cAMP–PKA signalling to trigger trap development. This work demonstrates that predatory fungi use multiple GPCRs to sense several distinct nematode-derived cues for prey recognition and to enable a switch to a predatory lifestyle. Identification of these receptors reveals the molecular mechanisms of cross-kingdom communication via conserved pheromones also sensed by plants and animals.

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 Dates: 2024-09
 Publication Status: Published online
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Title: Kiel Conference on Molecular Biology of Fungi 2024
Place of Event: Kiel, Germany
Start-/End Date: 2024-09-11 - 2024-09-13
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Title: Kiel Conference on Molecular Biology of Fungi
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 24 Identifier: -