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Abstract:
Behavior is tightly synchronized with bodily physiology. Internal needs
from the body drive behavior selection, while optimal behavior
performance requires a coordinated physiological response. Internal
state is dynamically represented by the nervous system to influence mood
and emotion, and body-brain signals also direct responses to external
sensory cues, enabling the organism to adapt and pursue its goals within
an ever-changing environment. In this review, we examine the anatomy and
function of the brain-body connection, manifested across local, reflex,
and central regulation levels. We explore these hierarchical loops in
the context of the immune system, specifically through the lens of
immunoception, and discuss the impact of its dysregulation on human
health.
