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Abstract:
Entomopathogenic fungi represent over 1,500 species that can infect insects (1). As powerful regulators of insect populations in nature, entomopathogenic fungi are well primed for use in biological pest control (2, 3). Additionally, an enhanced understanding of entomopathogenic fungi–host interactions is important for the protection of ecologically and economically important insect species (1). However, how fungi launch invasions against their insect hosts and how insects respond remain poorly understood. In PNAS, Tang et al. uncover a secreted protein, or effector, from fungi that blocks fly immunity and contributes to fungal virulence (4).