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  Fungal effector disables cathepsin-driven Toll immunity in insects

Tay, R., & Hsueh, Y.-P. (2025). Fungal effector disables cathepsin-driven Toll immunity in insects. Proceedings of the National Academy of Sciences of the United States of America, 122(8): e2500911122. doi:10.1073/pnas.2500911122.

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Tay, RJ, Author
Hsueh, Y-P1, Author                 
Affiliations:
1Department Complex Biological Interactions, Max Planck Institute for Biology Tübingen, Max Planck Society, ou_3603773              

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 Abstract: Entomopathogenic fungi represent over 1,500 species that can infect insects (1). As powerful regulators of insect populations in nature, entomopathogenic fungi are well primed for use in biological pest control (2, 3). Additionally, an enhanced understanding of entomopathogenic fungi–host interactions is important for the protection of ecologically and economically important insect species (1). However, how fungi launch invasions against their insect hosts and how insects respond remain poorly understood. In PNAS, Tang et al. uncover a secreted protein, or effector, from fungi that blocks fly immunity and contributes to fungal virulence (4).

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 Dates: 2025-02
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.2500911122
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: 3 Volume / Issue: 122 (8) Sequence Number: e2500911122 Start / End Page: - Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230