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  No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching

Raykov, P. P., Daly, J., Fisher, S. E., Eising, E., Geerligs, L., & Bird, C. M. (2025). No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching. Brain and Neuroscience Advances. Advance online publication, 9. doi:10.1177/23982128251314577.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0010-E061-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0010-E062-2
資料種別: 学術論文

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raykov-et-al-2025-no-effect-of-apolipoprotein-e-polymorphism-on-mri-brain-activity-during-movie-watching.pdf (出版社版), 3MB
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-0010-E063-1
ファイル名:
raykov-et-al-2025-no-effect-of-apolipoprotein-e-polymorphism-on-mri-brain-activity-during-movie-watching.pdf
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Hybrid
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公開
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application/pdf / [MD5]
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著作権日付:
2025
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作成者

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 作成者:
Raykov, Petar P.1, 著者
Daly, Jessica2, 著者
Fisher, Simon E.3, 4, 著者           
Eising, Else3, 著者           
Geerligs, Linda4, 著者
Bird, Chris M.2, 著者
所属:
1Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge,, Cambridge, UK, ou_persistent22              
2School of Psychology, University of Sussex, , Falmer, UK, ou_persistent22              
3Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
4Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              

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 要旨: Apolipoprotein E ε4 is a major genetic risk factor for Alzheimer’s disease, and some apolipoprotein E ε4 carriers show Alzheimer’s disease–related neuropathology many years before cognitive changes are apparent. Therefore, studying healthy apolipoprotein E genotyped individuals offers an opportunity to investigate the earliest changes in brain measures that may signal the presence of disease-related processes. For example, subtle changes in functional magnetic resonance imaging functional connectivity, particularly within the default mode network, have been described when comparing healthy ε4 carriers to ε3 carriers. Similarly, very mild impairments of episodic memory have also been documented in healthy apolipoprotein E ε4 carriers. Here, we use a naturalistic activity (movie watching), and a marker of episodic memory encoding (transient changes in functional magnetic resonance imaging activity and functional connectivity around so-called ‘event boundaries’), to investigate potential phenotype differences associated with the apolipoprotein E ε4 genotype in a large sample of healthy adults. Using Bayes factor analyses, we found strong evidence against existence of differences associated with apolipoprotein E allelic status. Similarly, we did not find apolipoprotein E-associated differences when we ran exploratory analyses examining: functional system segregation across the whole brain, and connectivity within the default mode network. We conclude that apolipoprotein E genotype has little or no effect on how ongoing experiences are processed in healthy adults. The mild phenotype differences observed in some studies may reflect early effects of Alzheimer’s disease–related pathology in apolipoprotein E ε4 carriers.

資料詳細

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言語: eng - English
 日付: 2025-01-312025
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1177/23982128251314577
 学位: -

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出版物 1

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出版物名: Brain and Neuroscience Advances. Advance online publication
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 9 通巻号: - 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): ISSN: 2398-2128
ISSN: 2398-2128