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  Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next-generation therapeutics

Bülbül, E. F., Bode, H. B., Schmitt, S., & Bozhüyük, K. A. J. (2025). Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next-generation therapeutics. Clinical and Translational Medicine, 15(2):. doi:10.1002/ctm2.70146.

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基本情報

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0010-E4D8-9 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0010-E4DC-5
資料種別: Review Article
その他のタイトル : Clinical and Translational Medicine

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OA-Status:
Gold

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 作成者:
Bülbül, Emre F.1, 著者
Bode, Helge B.2, 3, 4, 5, 6, 著者                 
Schmitt, Steven1, 著者
Bozhüyük, Kenan A. J.1, 著者
所属:
1external, ou_persistent22              
2Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266308              
3Chemical Biology, Department of Chemistry, Philipps University Marburg, Marburg, Germany, ou_persistent22              
4Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany, ou_persistent22              
5Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Frankfurt, Germany, External Organizations, ou_421891              
6Senckenberg Gesellschaft für Naturforschung, Frankfurt, ou_persistent22              

内容説明

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キーワード: AI, bioengineering, natural products, synthetic biology
 要旨: Abstract The eXchange Unit between Thiolation domains approach and artificial intelligence (AI)-driven tools like Synthetic Intelligence are transforming nonribosomal peptide synthetase and polyketide synthase engineering, enabling the creation of novel bioactive compounds that address critical challenges like antibiotic resistance and cancer. These innovations expand chemical space and optimize biosynthetic pathways, offering precise and scalable therapeutic solutions. Collaboration across synthetic biology, AI, and clinical research is essential to translating these breakthroughs into next-generation treatments and revolutionizing drug discovery and patient care.

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 日付: 2025-01-242025-02
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): URI: https://doi.org/10.1002/ctm2.70146
DOI: 10.1002/ctm2.70146
 学位: -

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出版物 1

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出版物名: Clinical and Translational Medicine
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Hoboken, New Jersey, USA : Wiley
ページ: - 巻号: 15 (2) 通巻号: e70146 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): その他: ISSN
CoNE: https://pure.mpg.de/cone/journals/resource/2001-1326