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  Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings

Sumarac, S., Youn, J., Fearon, C., Zivkovic, L., Keerthi, P., Flouty, O., et al. (2024). Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings. npj Parkinson's Disease, 10: 175. doi:10.1038/s41531-024-00773-4.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0010-E71B-C Version Permalink: https://hdl.handle.net/21.11116/0000-0010-E71C-B
Genre: Journal Article

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 Creators:
Sumarac, Srdjan1, Author
Youn, Jinyoung1, Author
Fearon, Conor1, Author
Zivkovic, Luka1, Author
Keerthi, Prerana2, Author
Flouty, Oliver1, Author
Popovic, Milos1, Author
Hodaie, Mojgan1, Author
Kalia, Suneil1, Author
Lozano, Andres1, Author
Hutchison, William1, Author
Fasano, Alfonso1, Author
Milosevic, Luka1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society, ou_3524333              

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 Abstract: Parkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12–21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4–8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21–30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.

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 Dates: 2024-09-12
 Publication Status: Issued
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 Identifiers: DOI: 10.1038/s41531-024-00773-4
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Title: npj Parkinson's Disease
Source Genre: Journal
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Publ. Info: London : Nature Publ. Group
Pages: - Volume / Issue: 10 Sequence Number: 175 Start / End Page: - Identifier: ISSN: 2373-8057
CoNE: https://pure.mpg.de/cone/journals/resource/2373-8057