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  Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings

Sumarac, S., Youn, J., Fearon, C., Zivkovic, L., Keerthi, P., Flouty, O., et al. (2024). Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings. npj Parkinson's Disease, 10: 175. doi:10.1038/s41531-024-00773-4.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0010-E71B-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-0010-E71C-B
Genre: Zeitschriftenartikel

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s41531-024-00773-4.pdf
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Copyright Datum:
2025
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http://creativecommons.org/licenses/by-nc-nd/4.0/

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 Urheber:
Sumarac, Srdjan1, Autor
Youn, Jinyoung1, Autor
Fearon, Conor1, Autor
Zivkovic, Luka1, Autor
Keerthi, Prerana2, Autor
Flouty, Oliver1, Autor
Popovic, Milos1, Autor
Hodaie, Mojgan1, Autor
Kalia, Suneil1, Autor
Lozano, Andres1, Autor
Hutchison, William1, Autor
Fasano, Alfonso1, Autor
Milosevic, Luka1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society, ou_3524333              

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 Zusammenfassung: Parkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12–21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4–8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21–30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.

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 Datum: 2024-09-12
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1038/s41531-024-00773-4
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Titel: npj Parkinson's Disease
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publ. Group
Seiten: - Band / Heft: 10 Artikelnummer: 175 Start- / Endseite: - Identifikator: ISSN: 2373-8057
CoNE: https://pure.mpg.de/cone/journals/resource/2373-8057