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  Lesion analysis of the brain areas involved in language comprehension

Dronkers, N. F., Wilkins, D. P., Van Valin Jr., R. D., Redfern, B. B., & Jaeger, J. J. (2004). Lesion analysis of the brain areas involved in language comprehension. Cognition, 92, 145-177. doi:10.1016/j.cognition.2003.11.002.

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資料種別: 学術論文

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Dronkers_Lesion_Analysis_Cognition_2004.pdf (出版社版), 757KB
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https://hdl.handle.net/11858/00-001M-0000-0012-6915-4
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Dronkers_Lesion_Analysis_Cognition_2004.pdf
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 作成者:
Dronkers, Nina F.1, 著者
Wilkins, David P.1, 著者
Van Valin Jr., Robert D.2, 著者           
Redfern, Brenda B.3, 著者
Jaeger, Jeri J.2, 著者
所属:
1University of California, Davis, Davis, CA, USA, ou_persistent22              
2University at Buffalo, State University of New York, Buffalo, NY, USA, ou_persistent22              
3VA Northern California Health Care System, Martinez, CA, USA, ou_persistent22              

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 要旨: The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss–Yamada Comprehensive Language Evaluation – Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss–Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448–450.) analysis along with the behavioral data. VLSM is a brain–behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension.

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言語: eng - English
 日付: 2004
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1016/j.cognition.2003.11.002
 学位: -

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出版物 1

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出版物名: Cognition
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Amsterdam : Elsevier
ページ: - 巻号: 92 通巻号: - 開始・終了ページ: 145 - 177 識別子(ISBN, ISSN, DOIなど): その他: 954925391298
その他: 0010-0277