ausblenden:
Schlagwörter:
Nucleotide-sequence; quinone oxidoreductase; escherichia-coli;
zeta-crystallin; synthase genes; cloning; mechanism;
identification; rubromycins; mithramycin
Zusammenfassung:
The telomerase inhibitor griseorhodin A is probably the most heavily oxidized bacterial polyketide known and features a unique epoxyspiroketal moiety crucial for its activity. To gain insight into which tailoring enzymes generate this pharmacophore, we
