ausblenden:
Schlagwörter:
Biosynthetic gene-cluster
Peptide synthetase
Microorganisms
Stigmatellin
Streptomyces
Diversity
Evolution
Cloning
Sponges
Fusion.
Biology in Current Contents(R)/Agricultural, Biology &
Environmental Sciences. Microbiology in Current Contents(R)/Life
Sciences.
Zusammenfassung:
Bacterial type I polyketide synthases (PKSs) produce a wide range of biomedically important secondary metabolites. These enzymes possess a modular structure that can be genetically re-engineered to yield novel drug candidates not found in nature. Recent