Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated 
ketoreductase domains from modular polyketide synthases

Siskos, A. P.; Baerga-Ortiz, A.; Bali, S.; Stein, V.; Mamdani, H.; Spiteller, D.; Popovic, B.; Spencer, J. B.; Staunton, J.; Weissman, K. J.; Leadlay, P. F.

doi:10.1016/j.chembiol.2005.08.017

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Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases

Siskos, A. P., Baerga-Ortiz, A., Bali, S., Stein, V., Mamdani, H., Spiteller, D., et al. (2005). Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology, 12(10), 1145-1153. doi:10.1016/j.chembiol.2005.08.017.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-A36E-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-370D-C

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Siskos, A. P., Author
Baerga-Ortiz, A., Author
Bali, S., Author
Stein, V., Author
Mamdani, H., Author
Spiteller, D.¹, Author
Popovic, B., Author
Spencer, J. B., Author
Staunton, J., Author
Weissman, K. J., Author
Leadlay, P. F., Author

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1Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society, ou_24028

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Free keywords: Fatty-acid synthase Erythromycin biosynthesis Chain extension 4-pro-s hydride Mechanism Binding Construction Antibiotics Specificity Expression Biochemistry & Biophysics in Current Contents(R)/Life Sciences

Abstract: A system is reported for the recombinant expression of individual ketoreductase (KR) domains from modular polyketide synthases (PKSs) and scrutiny of their intrinsic specificity and stereospecificity toward surrogate diketide substrates. The eryKR(1) an

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Dates: Date issued: 2005

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Identifiers: Other: BOL379
DOI: 10.1016/j.chembiol.2005.08.017

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Title: Chemistry & Biology

Other : Chem. Biol.

Source Genre: Journal

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Publ. Info: London : Cell Press

Pages: - Volume / Issue: 12 (10) Sequence Number: - Start / End Page: 1145 - 1153 Identifier: ISSN: 1074-5521
CoNE: https://pure.mpg.de/cone/journals/resource/954925604781