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  A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue

Spiteller, D., Waterman, C. L., & Spencer, J. B. (2005). A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue. Angewandte Chemie International Edition, 44(43), 7079-7082. doi:10.1002/anie.200501670.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-A39E-9 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-A4AB-1
Genre: Journal Article

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BOL380.pdf (Publisher version), 0B
 
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BOL380s1.pdf (Supplementary material), 129KB
 
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 Creators:
Spiteller, D.1, Author           
Waterman, C. L., Author
Spencer, J. B., Author
Affiliations:
1Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society, ou_24028              

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Free keywords: Biosynthesis Coenzymes Mass spectrometry Polyketides Synthases Pine pinus-sylvestris Stilbene synthase Acetyl-coenzyme Coa Inhibitor Enzymes Acid Chemistry & Analysis in Current Contents(R)/Life Sciences Chemistry in Current Contents(R)/Physical, Chemical & Earth Sciences
 Abstract: Trapped in the middle: To investigate the mechanistic details of polyketide biosynthesis, intermediates are trapped by a nonhydrolyzable malonyl‐coenzyme A analogue that reacts with a growing polyketide chain formed by a stilbene synthase. As the reverse transesterification reaction is not possible, the polyketide intermediates accumulate attached to the analogue (see scheme; Enz=enzyme, CoA=coenzyme A).

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 Dates: 2005
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: Other: BOL380
DOI: 10.1002/anie.200501670
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Title: Angewandte Chemie International Edition
  Other : Angew. Chem., Int. Ed.
  Other : Angewandte Chemie, International Edition
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 44 (43) Sequence Number: - Start / End Page: 7079 - 7082 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851