English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts

Muglia, P., Tozzi, F., Galwey, N. W., Francks, C., Upmanyu, R., Kong, X., et al. (2010). Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Molecular Psychiatry, 15(6), 589-601. doi:10.1038/mp.2008.131.

Item is

Files

show Files
hide Files
:
Muglia_Genome_wide_Molecular_Psych_2010.pdf (Publisher version), 219KB
Name:
Muglia_Genome_wide_Molecular_Psych_2010.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Muglia, P., Author
Tozzi, F., Author
Galwey, N. W. , Author
Francks, Clyde1, 2, 3, Author              
Upmanyu, R., Author
Kong, X.Q., Author
Antoniades, A., Author
Domenici, E., Author
Perry, J., Author
Rothen, S., Author
Vandeleur, C. L., Author
Mooser, V., Author
Waeber, G., Author
Vollenweider, P., Author
Preisig, M., Author
Lucae, S., Author
Muller-Myhsok, B., Author
Holsboer, F., Author
Middleton, L. T., Author
Roses, A. D., Author
Affiliations:
1Genetics Division, Drug Discovery, GlaxoSmithKline R&D, , Verona, Italy, ou_persistent22              
2Language and Genetics Group, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_55213              
3Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              

Content

show
hide
Free keywords: -
 Abstract: Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the variant of MDD characterized by recurrent episodes of depression. Genetic studies have thus far failed to identify clear and consistent evidence of genetic risk factors for MDD. We conducted a genome-wide association study (GWAS) in two independent datasets. The first GWAS was performed on 1022 recurrent MDD patients and 1000 controls genotyped on the Illumina 550 platform. The second was conducted on 492 recurrent MDD patients and 1052 controls selected from a population-based collection, genotyped on the Affymetrix 5.0 platform. Neither GWAS identified any SNP that achieved GWAS significance. We obtained imputed genotypes at the Illumina loci for the individuals genotyped on the Affymetrix platform, and performed a meta-analysis of the two GWASs for this common set of approximately half a million SNPs. The meta-analysis did not yield genome-wide significant results either. The results from our study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in our datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays. Meta-analysis of larger datasets is warranted to identify SNPs with smaller effects or with rarer allele frequencies that contribute to the risk of MDD.

Details

show
hide
Language(s): eng - English
 Dates: 20082010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/mp.2008.131
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Houndmills, Hampshire, UK : Stockton Press
Pages: - Volume / Issue: 15 (6) Sequence Number: - Start / End Page: 589 - 601 Identifier: Other: 954925619131
ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131