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  Failure to replicate effect of Kibra on human memory in two large cohorts of European origin

Need, A. C., Attix, D. K., McEvoy, J. M., Cirulli, E. T., Linney, K. N., Wagoner, A. P., et al. (2008). Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 667-668. doi:10.1002/ajmg.b.30658.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-C950-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-C956-E
Genre: Journal Article

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Need_Failure_to_replicate_Am_Jou_Med_GenPt_B.pdf (Publisher version), 41KB
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Supplementary Method I - Story recall and list learning in the Duke Genetics of Memory Cohort.
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Supplementary Method II - List learning in the German cohort. [ajmgb30658-SupplementaryMethodsAmJMedGen10thAugust.doc renamed to sm_file_AJMGB30658_2.doc]
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 Creators:
Need, Anna C., Author
Attix, Deborah K., Author
McEvoy, Jill M., Author
Cirulli, Elizabeth T., Author
Linney, Kristen N., Author
Wagoner, Ana Patricia, Author
Gumbs, Curtis E., Author
Giegling, Ina, Author
Möller, Hans-Jürgen , Author
Francks, Clyde1, Author           
Muglia, Pierandrea, Author
Roses, Allen, Author
Gibson, Greg, Author
Weale, Mike E., Author
Rujescu, Dan, Author
Goldstein, David B., Author
Affiliations:
1GlaxoSmithKline, RTP, North Carolina, ou_persistent22              

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 Abstract: It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/ajmg.b.30658
PMID: 1820517
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Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  Other : Am. J. Med. Genet.
Source Genre: Journal
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Publ. Info: Hoboken, N.J. : Wiley-Liss
Pages: - Volume / Issue: 147B Sequence Number: - Start / End Page: 667 - 668 Identifier: Other: 1000000000019780
Other: 0148-7299
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000019780_1