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  Pancreatic beta-cells: From generation to regeneration.

Collombat, P., Xiaobo, X., Heimberg, H., & Mansouri, A. (2010). Pancreatic beta-cells: From generation to regeneration. Seminars in Cell and Developmental Biology, 21(8), 838-844. doi:10.1016/j.semcdb.2010.07.007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-D4FC-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F26B-9
Genre: Journal Article

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 Creators:
Collombat, P.1, Author              
Xiaobo, X., Author
Heimberg, H., Author
Mansouri, A.1, Author              
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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Free keywords: Pancreas; Stem cells; Regeneration; Mouse; Diabetes
 Abstract: The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprising alpha-, beta-, delta-, epsilon- and PP-cells, producing the hormones glucagon, insulin, somatostatin, ghrelin and pancreatic polypeptide (PP), respectively. Insulin-producing beta-cells play a central role in the control of the glucose homeostasis. Accordingly, absolute or relative deficiency in beta-cells may ultimately lead to type 1 and/or type 2 diabetes, respectively. One major goal of diabetes research is therefore to understand the molecular mechanisms controlling the development of beta-cells during pancreas morphogenesis, but also those underlying the regeneration of adult injured pancreas, and assess their significance for future cell-based therapy. In this review, we will therefore present new insights into beta-cell development with focus on beta-cell regeneration.

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Language(s): eng - English
 Dates: 2010-08-032010-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 515328
DOI: 10.1016/j.semcdb.2010.07.007
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Title: Seminars in Cell and Developmental Biology
Source Genre: Journal
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Pages: - Volume / Issue: 21 (8) Sequence Number: - Start / End Page: 838 - 844 Identifier: -