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  A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes.

Günesdogan, U., Jäckle, H., & Herzig, A. (2010). A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. EMBO Reports, 11(10), 772-776. doi:10.1038/embor.2010.124.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-D520-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F253-E
Genre: Journal Article

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 Creators:
Günesdogan, U.1, Author              
Jäckle, H.1, Author              
Herzig, A.1, Author              
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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Free keywords: Histone deletion; Histone transgenes; Functional assay; Drosophila melanogaster
 Abstract: Despite the fundamental role of canonical histones in nucleosome structure, there is no experimental system for higher eukaryotes in which basic questions about histone function can be directly addressed. We developed a new genetic tool for Drosophila melanogaster in which the canonical histone complement can be replaced with multiple copies of experimentally modified histone transgenes. This new histone‐replacement system provides a well‐defined and direct cellular assay system for histone function with which to critically test models in chromatin biology dealing with chromatin assembly, variant histone functions and the biological significance of distinct histone modifications in a multicellular organism.

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Language(s): eng - English
 Dates: 2010-09-032010-10-01
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: EMBO Reports
Source Genre: Journal
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Pages: - Volume / Issue: 11 (10) Sequence Number: - Start / End Page: 772 - 776 Identifier: -