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  Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag.

Kiessling, S., Eichele, G., & Oster, H. (2010). Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag. Journal of Clinical Investigation, 120(7), 2600-2609. doi:10.1172/JCI41192.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-D564-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F259-2
Genre: Journal Article

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 Creators:
Kiessling, S.1, Author              
Eichele, G.1, Author              
Oster, H.2, Author              
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              
2Research Group on Circadian Rythms, MPI for biophysical chemistry, Max Planck Society, ou_578594              

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 Abstract: Jet lag encompasses a range of psycho- and physiopathological symptoms that arise from temporal misalignment of the endogenous circadian clock with external time. Repeated jet lag exposure, encountered by business travelers and airline personnel as well as shift workers, has been correlated with immune deficiency, mood disorders, elevated cancer risk, and anatomical anomalies of the forebrain. Here, we have characterized the molecular response of the mouse circadian system in an established experimental paradigm for jet lag whereby mice entrained to a 12-hour light/12-hour dark cycle undergo light phase advancement by 6 hours. Unexpectedly, strong heterogeneity of entrainment kinetics was found not only between different organs, but also within the molecular clockwork of each tissue. Manipulation of the adrenal circadian clock, in particular phase-shifting of adrenal glucocorticoid rhythms, regulated the speed of behavioral reentrainment. Blocking adrenal corticosterone either prolonged or shortened jet lag, depending on the time of administration. This key role of adrenal glucocorticoid phasing for resetting of the circadian system provides what we believe to be a novel mechanism-based approach for possible therapies for jet lag and jet lag–associated diseases.

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Language(s): eng - English
 Dates: 2010-07-012010
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: eDoc: 510637
DOI: 10.1172/JCI41192
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Title: Journal of Clinical Investigation
Source Genre: Journal
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Pages: - Volume / Issue: 120 (7) Sequence Number: - Start / End Page: 2600 - 2609 Identifier: -