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  Reprogramming into pancreatic endocrine cells based on developmental cues.

Kordowich, S., Mansouri, A., & Collombat, P. (2010). Reprogramming into pancreatic endocrine cells based on developmental cues. Mollecular and Cellular Endocrinology, 315(1-2), 11-18. doi:10.1016/j.mce.2009.10.015.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-D62D-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F26C-7
Genre: Journal Article

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446583.pdf (Publisher version), 0B
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 Creators:
Kordowich, S.1, Author              
Mansouri, A.1, Author              
Collombat, P., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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Free keywords: Endocrine pancreas development; Arx; Pax4; Mouse; Diabetes; Fate specification
 Abstract: Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therapies, alternative treatments need to be established. In order to compensate the beta-cell deficiency associated with type 1 diabetes, current research focuses on new strategies to generate insulin-producing beta-cells for transplantation purpose, including the differentiation of stem or progenitor cells, as well as the transdifferentiation of dispensable mature cell types. However, to successfully force specific cells to adopt a functional beta-cell fate or phenotype, a better understanding of the molecular mechanisms underlying beta-cell genesis is required. The present short review summarizes the hitherto known functions and interplays of several key factors involved in the development of the different endocrine cell lineages during pancreas morphogenesis, as well as their potential to direct the generation of beta-cells. Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated.

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Language(s): eng - English
 Dates: 2010-02-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 446583
DOI: 10.1016/j.mce.2009.10.015
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Title: Mollecular and Cellular Endocrinology
Source Genre: Journal
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Pages: - Volume / Issue: 315 (1-2) Sequence Number: - Start / End Page: 11 - 18 Identifier: -