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  Dual lipolytic control of body fat storage and mobilization in Drosophila

Groenke, S., Mueller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., et al. (2007). Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biology, 5(6), 1248-1256. Retrieved from http://biology.plosjournals.org/perlserv/?request=get-pdf&file=10.1371_journal.pbio.0050137-S.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-E12E-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-D9AD-C
Genre: Journal Article

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 Creators:
Groenke, S.1, Author              
Mueller, G., Author
Hirsch, J., Author
Fellert, S.1, Author              
Andreou, A.1, Author              
Haase, T., Author
Jaeckle, H.1, Author              
Kuehnlein, R. P.2, Author              
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
2Research Group of Molecular Physiology, MPI for biophysical chemistry, Max Planck Society, ou_578592              

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 Abstract: Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ß-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.

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Language(s): eng - English
 Dates: 2007-05-08
 Publication Status: Published in print
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Title: PLoS Biology
Source Genre: Journal
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Pages: - Volume / Issue: 5 (6) Sequence Number: - Start / End Page: 1248 - 1256 Identifier: -