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  The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release

Wadel, K., Neher, E., & Sakaba, T. (2007). The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release. Neuron, 53(4), 563-575. doi:10.1016/j.neuron.2007.01.021.

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Genre: Zeitschriftenartikel
Andere : The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release

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 Urheber:
Wadel, K.1, Autor           
Neher, E.2, Autor           
Sakaba, T.1, Autor           
Affiliations:
1Research Group of Biophysics of Synaptic Transmission, MPI for biophysical chemistry, Max Planck Society, ou_578583              
2Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Zusammenfassung: In order to release neurotransmitter synchronously in response to a presynaptic action potential, synaptic vesicles must be both release competent and located close to presynaptic Ca2+ channels. It has not been shown, however, which of the two is the more decisive factor. We tested this issue at the calyx of Held synapse by combining Ca2+ uncaging and electrophysiological measurements of postsynaptic responses. After depletion of the synaptic vesicles that are responsible for synchronous release during action potentials, uniform elevation of intracellular Ca2+ by Ca2+ uncaging could still elicit rapid release. The Ca2+ sensitivity of remaining vesicles was reduced no more than 2-fold, which is insufficient to explain the slow-down of the kinetics of release (10-fold) observed during a depolarizing pulse. We conclude that recruitment of synaptic vesicles to sites where Ca2+ channels cluster, rather than fusion competence, is a limiting step for rapid neurotransmitter release in response to presynaptic action potentials.

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Sprache(n): eng - English
 Datum: 2007-02-15
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuron.2007.01.021
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Titel: Neuron
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 53 (4) Artikelnummer: - Start- / Endseite: 563 - 575 Identifikator: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565