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  Clustering and diversity of fluctuations for proteins

Demirel, M. C., & Cherny, D. I. (2005). Clustering and diversity of fluctuations for proteins. Journal of Nanomedicine, 1(1): doi:10.1016/j.nano.2004.11.007, pp. 41-46. Retrieved from http://www.nanomedjournal.com/article/S1549-9634(05)00008-0/fulltext.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-E9E8-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-DAFE-0
Genre: Journal Article

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210748.pdf (Publisher version), 0B
 
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 Creators:
Demirel, M. C., Author
Cherny, D. I.1, Author              
Affiliations:
1Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society, ou_578628              

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Free keywords: Protein fluctuations; Elastic network model; Simulated annealing
 Abstract: We have studied the fluctuations of proteins employing a new approach. An annealing algorithm is used to generate a 3-dimensional protein structure from the contact map. First, we study the building diversities of structural elements by adding individual structures (domains or sub-domains). Thereafter, we focus on the properties of structural elements based on fluctuations. Low and high fluctuations of structural regions can be grouped depending on the level of fluctuations in each region. To verify our hypothesis, we analyzed the pattern of fluctuations for chymotrypsin inhibitor-2 (CI2) by unstructuring (melting) of sub-regions. Our approach introduces a new concept for classifying building blocks of proteins based on thermal fluctuations.

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Language(s): eng - English
 Dates: 2005-04-042005-03
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
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Title: Journal of Nanomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 1 (1) Sequence Number: doi:10.1016/j.nano.2004.11.007 Start / End Page: 41 - 46 Identifier: -