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  Adaptation of nanoarrays for the study of α-synuclein aggregation - preliminary results

Dietrich, H. R. C., van den Doel, R. L., Hoyer, W., van Oel, W., Lung, G. L., Garini, Y., et al. (2005). Adaptation of nanoarrays for the study of α-synuclein aggregation - preliminary results. In D. Nicolau (Ed.), Imaging, manipulation, and analysis of biomolecules and cells: fundamentals and applications III (pp. 395-402). Bellingham, Wash.: Society of Photo Optical Instrumentation Engineers.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-E9F4-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-DAFA-7
Genre: Book Chapter

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 Creators:
Dietrich, H. R. C., Author
van den Doel, R. L., Author
Hoyer, W.1, Author              
van Oel, W., Author
Lung, G. L., Author
Garini, Y., Author
Jovin, T. M.1, Author              
Young, I. T., Author
Affiliations:
1Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society, ou_578628              

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Free keywords: Nanoarrays; High Throughput Screening; Evaporation Control; α-Synuclein; Thioflavin T; Quantitative Fluorescence Microscopy
 Abstract: In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.

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Language(s): eng - English
 Dates: 2005-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 245856
 Degree: -

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Title: Imaging, manipulation, and analysis of biomolecules and cells: fundamentals and applications III
Source Genre: Book
 Creator(s):
Nicolau, D.V., Editor
Affiliations:
-
Publ. Info: Bellingham, Wash. : Society of Photo Optical Instrumentation Engineers
Pages: - Volume / Issue: - Sequence Number: DOI: 10.1117/12.587493 Start / End Page: 395 - 402 Identifier: -

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Title: SPIE Proceedings
Source Genre: Series
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Publ. Info: -
Pages: - Volume / Issue: 5699 Sequence Number: - Start / End Page: - Identifier: -