English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.

Mecklenbraeuker, I., Kalled, S. L., Leitges, M., Mackay, F., & Tarakhovsky, A. (2004). Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature, 431(7007), 456-461. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15361883.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-EC32-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8A04-5
Genre: Journal Article

Files

show Files
hide Files
:
270903.pdf (Publisher version), 0B
Name:
270903.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Mecklenbraeuker, I., Author
Kalled, S. L., Author
Leitges, M.1, Author              
Mackay, F., Author
Tarakhovsky, A., Author
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              

Content

show
hide
Free keywords: Animals; B-Lymphocytes/cytology/enzymology/metabolism; Cell Death; Cell Nucleus/enzymology/metabolism; Cell Survival; Cells, Cultured; Fibroblasts; Membrane Proteins/metabolism; Mice; Phosphorylation; Protein Kinase C/deficiency/genetics/metabolism; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Signal Transduction; Tumor Necrosis Factor-alpha/metabolism
 Abstract: Approximately 65% of B cells generated in human bone marrow are potentially harmful autoreactive B cells. Most of these cells are clonally deleted in the bone marrow, while those autoreactive B cells that escape to the periphery are anergized or perish before becoming mature B cells. Escape of self-reactive B cells from tolerance permits production of pathogenic auto-antibodies; recent studies suggest that extended B lymphocyte survival is a cause of autoimmune disease in mice and humans. Here we report a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKCdelta): spontaneous death of resting B cells is regulated by nuclear localization of PKCdelta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B). We show that treatment of B cells with the potent B-cell survival factor BAFF ('B-cell-activating factor belonging to the TNF family') prevents nuclear accumulation of PKCdelta. Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival.

Details

show
hide
Language(s): eng - English
 Dates: 2004-09-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 431 (7007) Sequence Number: - Start / End Page: 456 - 461 Identifier: -