English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments

Bussen, M., Petry, M., Schuster-Gossler, K., Leitges, M., Gossler, A., & Kispert, A. (2004). The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes and Development, 18(10), 1209-1221. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15155583.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-ED55-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C155-2
Genre: Journal Article

Files

show Files
hide Files
:
270901.pdf (Publisher version), 0B
Name:
270901.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Bussen, M., Author
Petry, M., Author
Schuster-Gossler, K., Author
Leitges, M.1, Author              
Gossler, A., Author
Kispert, A., Author
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              

Content

show
hide
Free keywords: Animals ; Base Sequence ; Body Patterning/genetics/*physiology ; DNA/genetics ; Gene Expression Regulation, Developmental ; Gene Targeting ; Genetic Markers ; In Situ Hybridization ; Mice ; Mice, Knockout ; Mice, Transgenic ; Peripheral Nerves/embryology ; Research Support, Non-U.S. Gov't ; Somites/*cytology ; Spine/abnormalities/embryology ; Transcription Factors/genetics/*physiology
 Abstract: The compartmentalization of somites along their anterior-posterior (AP) axis is pivotal to the segmental organization of the vertebrate axial skeleton and the peripheral nervous system. Anterior and posterior somite halves contribute to different vertebral elements. They are also characterized by different proliferation rates and properties with respect to neural crest cell migration and spinal nerve passage. AP-somite polarity is generated in the anterior presomitic mesoderm by Mesp2 and Delta/Notch signaling. Here, we demonstrate that maintenance of AP-somite polarity is mediated by the T-box transcription factor Tbx18. Mice deficient for Tbx18 show expansion of pedicles with transverse processes and proximal ribs, elements derived from the posterior lateral sclerotome. AP-somite polarity is established in Tbx18 mutant embryos but is not maintained. During somite maturation, posterior somite compartments expand most likely because of posterior cells invading the anterior somite half. In the anterior lateral sclerotome, Tbx18 acts as an antiapoptotic factor. Ectopic expression experiments suggest that Tbx18 can promote anterior at the expense of posterior somite compartments. In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments.

Details

show
hide
Language(s): eng - English
 Dates: 2004-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes and Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 18 (10) Sequence Number: - Start / End Page: 1209 - 1221 Identifier: -