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  Functional somatotopy of finger representations in human primary motor cortex

Dechent, P., & Frahm, J. (2003). Functional somatotopy of finger representations in human primary motor cortex. Human Brain Mapping, 18(4), 272-283. Retrieved from http://www3.interscience.wiley.com/cgi-bin/fulltext/103020944/PDFSTART.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F12B-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E4EB-7
Genre: Journal Article

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Dechent, P.1, Author              
Frahm, J.1, Author              
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1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: functional MRI; primary motor cortex; finger somatotopy; human
 Abstract: To assess the degree of fine-scale somatotopy within the hand area of the human primary motor cortex (M1), functional mapping of individual movements of all fingers was performed in healthy young subjects (n = 7) using MRI at 0.8 x 0.8 mm(2) resolution and 4 mm section thickness. The experimental design comprised both a direct paradigm contrasting single digit movements vs. motor rest and multiple differential paradigms contrasting single digit movements vs. the movement of another digit. Direct mapping resulted in largely overlapping activations. A somatotopic arrangement was only recognizable when considering the mean center-of-mass coordinates of individual digit representations averaged across subjects. In contrast, differential paradigms revealed more segregated and somatotopically ordered activations in single subjects. The use of center-of-mass coordinates yielded inter-digit distances ranging from 2.0 to 16.8 mm, which reached statistical significance for pairs of more distant digits. For the middle fingers, the functional somatotopy obtained by differential mapping was dependent on the choice of the digit used for control. These results confirm previous concepts that finger somatotopy in the human M1 hand area emerges as a functional predominance of individual digit representations sharing common areas in a distributed though ordered network. Hum. Brain Mapping 18:272-283, 2003. (C) 2003 Wiley-Liss, Inc.

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Language(s): eng - English
 Dates: 2003-04
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
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Title: Human Brain Mapping
Source Genre: Journal
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Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 272 - 283 Identifier: -