English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

Altrock, W. D., Dieck, S. T., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., et al. (2003). Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron, 37(5), 787-800. Retrieved from http://download.cell.com/neuron/pdf/PIIS0896627303000886.pdf.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F146-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-D663-6
Genre: Journal Article

Files

show Files
hide Files
:
599250.pdf (Publisher version), 700KB
Name:
599250.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Altrock, W. D., Author
Dieck, S. T., Author
Sokolov, M., Author
Meyer, A. C., Author
Sigler, A.1, Author              
Brakebusch, C., Author
Fassler, R., Author
Richter, K., Author
Boeckers, T. M., Author
Potschka, H., Author
Brandt, C., Author
Loscher, W., Author
Grimberg, D., Author
Dresbach, T., Author
Hempelmann, A., Author
Hassan, H., Author
Balschun, D., Author
Frey, J. U., Author
Brandstaetter, J. H., Author
Garner, C. C., Author
Rosenmund, C.1, Author              Gundelfinger, E. D., Author more..
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

Content

show
hide
Free keywords: -
 Abstract: Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.

Details

show
hide
Language(s): eng - English
 Dates: 2003-03-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 37 (5) Sequence Number: - Start / End Page: 787 - 800 Identifier: -