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  Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

Altrock, W. D., Dieck, S. T., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., et al. (2003). Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron, 37(5), 787-800. Retrieved from http://download.cell.com/neuron/pdf/PIIS0896627303000886.pdf.

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Altrock, W. D., Author
Dieck, S. T., Author
Sokolov, M., Author
Meyer, A. C., Author
Sigler, A.1, Author           
Brakebusch, C., Author
Fassler, R., Author
Richter, K., Author
Boeckers, T. M., Author
Potschka, H., Author
Brandt, C., Author
Loscher, W., Author
Grimberg, D., Author
Dresbach, T., Author
Hempelmann, A., Author
Hassan, H., Author
Balschun, D., Author
Frey, J. U., Author
Brandstaetter, J. H., Author
Garner, C. C., Author
Rosenmund, C.1, Author           Gundelfinger, E. D., Author more..
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.

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Language(s): eng - English
 Dates: 2003-03-06
 Publication Status: Issued
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 Rev. Type: Peer
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 37 (5) Sequence Number: - Start / End Page: 787 - 800 Identifier: -