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  Modulated nucleoside kinases as tools to improve the activation of therapeutic nucleoside analogues

Monnerjahn, C., & Konrad, M. (2003). Modulated nucleoside kinases as tools to improve the activation of therapeutic nucleoside analogues. ChemBioChem, 4(2-3), 143-146. Retrieved from http://www3.interscience.wiley.com/cgi-bin/fulltext/103520676/PDFSTART.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F148-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E3DC-2
Genre: Journal Article

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 Creators:
Monnerjahn, C.1, Author              
Konrad, M.2, Author              
Affiliations:
1Department of Molecular Genetics, MPI for biophysical chemistry, Max Planck Society, ou_578622              
2Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578612              

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Free keywords: cancer; human immunodeficiency virus; nucleoside analogues; protein design; thymidylate kinase
 Abstract: The use of nucleoside anaolgues in anticancer and antiviral treatments is often impaired by the slow intracellular activation of these drugs. This problem can be addressed by the modulation of rate-limiting enzymes in the activation pathways of the nucleoside analogues. Therapeutic strategies based on the combination of optimized activating enzymes and established nucleoside drugs promise significant improvements to traditional chemotherapy.

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Language(s): eng - English
 Dates: 2003-03-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: ChemBioChem
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 4 (2-3) Sequence Number: - Start / End Page: 143 - 146 Identifier: -