English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Estimation of quantal parameters at the calyx of Held synapse

Sakaba, T., Schneggenburger, R., & Neher, E. (2002). Estimation of quantal parameters at the calyx of Held synapse. Neuroscience Research, 44(4), 343-356. doi:10.1016/S0168-0102(02)00174-8.

Item is

Files

show Files
hide Files
:
124036.pdf (Publisher version), 0B
 
File Permalink:
-
Name:
124036.pdf
Description:
-
OA-Status:
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Sakaba, T.1, Author           
Schneggenburger, R.2, Author           
Neher, E.3, Author           
Affiliations:
1Research Group of Biophysics of Synaptic Transmission, MPI for biophysical chemistry, Max Planck Society, ou_578583              
2Research Group of Synaptic Dynamics and Modulation, MPI for Biophysical Chemistry, Max Planck Society, ou_578582              
3Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

Content

show
hide
Free keywords: -
 Abstract: The calyx of Held has recently emerged as a convenient model system to study CNS synapses. In order to understand the mechanisms of synaptic transmission and short-term synaptic plasticity, quantal parameters and their changes should be estimated precisely. For this purpose, various methods have been applied to the calyx of Held synapse. The results confirm many aspects of the early findings on transmission at the neuromuscular junction. On the other hand, the simplest quantal hypothesis does not work at the calyx of Held, because of additional factors such as heterogeneous release probability of synaptic vesicles, intra- and intersite quantal variability, an overlap of facilitation and depression of transmitter release, changes in quantal sizes due to desensitization and saturation of postsynaptic receptors, and delayed clearance of transmitter from the synaptic cleft. These factors should always be taken into account for fully understanding the mechanisms of synaptic transmission and plasticity.

Details

show
hide
Language(s): eng - English
 Dates: 2002-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0168-0102(02)00174-8
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuroscience Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Shannon : Elsevier
Pages: - Volume / Issue: 44 (4) Sequence Number: - Start / End Page: 343 - 356 Identifier: ISSN: 0168-0102
CoNE: https://pure.mpg.de/cone/journals/resource/954925484695