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  Guidance of primordial germ cell migration by the chemokine SDF-1

Doitsidou, M., Reichman-Fried, M., Stebler, J., Koeprunner, M., Doerries, J., Meyer, D., et al. (2002). Guidance of primordial germ cell migration by the chemokine SDF-1. Cell, 111(5), 647-659. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-4C5HF3Y-7-1&_cdi=7051&_user=38661&_pii=S0092867402011352&_orig=search&_coverDate=11%2F27%2F2002&_sk=998889994&view=c&wchp=dGLzVzz-zSkzk&md5=857d4dd3ce4880405a3b1a492fadce0f&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F288-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-9D14-4
Genre: Journal Article

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 Creators:
Doitsidou, M.1, Author              
Reichman-Fried, M.1, Author              
Stebler, J.1, Author              
Koeprunner, M.1, Author              
Doerries, J.2, Author              
Meyer, D., Author
Esguerra, C. V., Author
Leung, T., Author
Raz, E.1, Author              
Affiliations:
1Research Group of Germ Cell Development, MPI for biophysical chemistry, Max Planck Society, ou_578603              
2Research Group of Nuclear Architecture, MPI for biophysical chemistry, Max Planck Society, ou_578575              

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 Abstract: The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are found and toward which they migrate in wild-type as well as in mutant embryos in which PGC migration is abnormal. Knocking down SDF-1 or its receptor CXCR4 results in severe defects in PGC migration. Specifically, PGCs that do not receive the SDF-1 signal exhibit lack of directional movement toward their target and arrive at ectopic positions within the embryo. Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs.

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Language(s): eng - English
 Dates: 2002-11-27
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 111 (5) Sequence Number: - Start / End Page: 647 - 659 Identifier: -