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  Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle

Baeumer, N., Marquardt, T., Stoykova, A., Ashery-Padan, R., Chowdhury, K., & Gruss, P. (2002). Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development, 129(19), 4535-4545. Retrieved from http://dev.biologists.org/content/129/19/4535.full.pdf+html.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F2D8-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-0B1A-8
Genre: Journal Article

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 Creators:
Baeumer, N.1, Author              
Marquardt, T.1, Author              
Stoykova, A.2, Author              
Ashery-Padan, R.1, Author              
Chowdhury, K.2, Author              
Gruss, P.1, Author              
Affiliations:
1Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              
2Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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Free keywords: Pax6; enhancer; retina; autoregulation; axon guidance; superior colliculus; axis formation; BF-1; BF-2; mousetû
 Abstract: The establishment of polarity is an important step during organ development. We assign a function for the paired and homeodomain transcription factor Pax6 in axis formation in the retina. Pax6 is a key factor of the highly conserved genetic network implic ated in directing the initial phases of eye development. We recently demonstrated that Pax6 is also essential for later aspects of eye development, such as lens formation and retinogenesis. In this study, we present evidence that a highly conserved intron ic enhancer, alpha, in the Pax6 gene is essential for the establishment of a distal(high)- proximal(low) gradient of Pax6 activity in the retina. In the mature retina, the activity mediated by the alpha-enhancer defines a population of retinal ganglion ce lls that project to two sickle-shaped domains in the superior colliculus and lateral geniculate nucleus. Deletion of the alpha-enhancer in vivo revealed that retinal Pax6 expression is regulated in two complementary topographic domains. We found that P ax6 activity is required for the establishment, as well as the maintenance of dorsal and nasotemporal characteristics in the optic vesicle and, later, the optic cup.t

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Language(s): eng - English
 Dates: 2002-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Development
Source Genre: Journal
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Pages: - Volume / Issue: 129 (19) Sequence Number: - Start / End Page: 4535 - 4545 Identifier: -