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  Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans

Karabinos, A., Schulze, E., Klisch, T., Wang, J., & Weber, K. (2002). Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans. Mechanisms of Development, 117(1-2), 311-314. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9H-46572X4-1-9&_cdi=5115&_user=38661&_pii=S0925477302001922&_origin=search&_coverDate=09%2F30%2F2002&_sk=998829998&view=c&wchp=dGLzVlb-zSkWA&md5=973992c4b8f53bcbc41f5c49934f34fb&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F31E-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0EE3-B
Genre: Journal Article

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Karabinos, A.1, Author              
Schulze, E., Author
Klisch, T., Author
Wang, J.1, Author              
Weber, K.1, Author              
Affiliations:
1Department of Biochemistry and Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578618              

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Free keywords: Caenorhabditis elegans; desmosomes; hypodermis; intermediate filament; promoter
 Abstract: The multigene family of intermediate filament (IF) proteins in Caenorhabditis elegans covers 11 members of which four (A1-3, B1) are essential for development. Suppression of a fifth gene (C2) results in a dumpy phenotype. Expression patterns of three essential genes (A1, A3, B1) were already reported. To begin to analyze the two remaining RNAi phenotypes we followed the expression of the A2 and C2 proteins. Expression of A2 mRNA starts in larval stage L1 and continues in the adult. Transgenic A2 promoter/gfp larvae strongly display GFP in the main body hypodermis but not in seam cells. This pattern and the muscle displacement/paralysis induced by RNAi silencing are consistent with the role of this protein in keeping the correct hypodermis/muscle relationship during development. IF protein C2 occurs in the cytoplasm and desmosomes of intestinal cells and in pharynx desmosomes. Expression of C2 starts in the late embryo and persists in all further stages. (C) 2002 Published by Elsevier Science Ireland Ltd.

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Language(s): eng - English
 Dates: 2002-09
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Mechanisms of Development
Source Genre: Journal
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Pages: - Volume / Issue: 117 (1-2) Sequence Number: - Start / End Page: 311 - 314 Identifier: -