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  Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6sey/sey double-mutant mice

Muzio, L., DiBenedetto, B., Stoykova, A., Boncinelli, E., Gruss, P., & Mallamaci, A. (2002). Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6sey/sey double-mutant mice. Nature Neuroscience, 5(8), 737-745. Retrieved from http://www.nature.com/neuro/journal/v5/n8/pdf/nn892.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F354-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-91A9-1
Genre: Journal Article

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Muzio, L., Author
DiBenedetto, B., Author
Stoykova, A.1, Author              
Boncinelli, E., Author
Gruss, P.2, Author
Mallamaci, A., Author
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1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              
2Max Planck Society, ou_persistent13              

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 Abstract: The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to stably activate morphogenesis of cerebral cortex and to repress that of adjacent structures, such as striatum.

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Language(s): eng - English
 Dates: 2002-08
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Nature Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 5 (8) Sequence Number: - Start / End Page: 737 - 745 Identifier: -