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  Molecular cloning and functional characterization of human vesicular glutamate transporter 3

Takamori, S., Malherbe, P., Broger, C., & Jahn, R. (2002). Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Reports, 3(8), 798-803. Retrieved from http://www.nature.com/embor/journal/v3/n8/pdf/embor099.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F35A-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E458-4
Genre: Journal Article

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16644.pdf (Publisher version), 0B
 
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 Creators:
Takamori, S.1, Author              
Malherbe, P., Author
Broger, C., Author
Jahn, R.1, Author              
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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 Abstract: Glutamate is the major excitatory neurotransmitter in the mammalian CNS. It is loaded into synaptic vesicles by a proton gradient-dependent uptake system and is released by exocytosis upon stimulation. Recently, two mammalian isoforms of a vesicular glutamate transporter, VGLUT1 and VGLUT2, have been identified, the expression of which enables quantal release of glutamate from glutamatergic neurons. Here, we report a novel isoform of a human vesicular glutamate transporter (hVGLUT3). The predicted amino acid sequence of hVGLUT3 shows 72% identity to both hVGLUT1 and hVGLUT2. hVGLUT3 functions as a vesicular glutamate transporter with similar properties to the other isoforms when it is heterologously expressed in a neuroendocrine cell line. Although mammalian VGLUT1 and VGLUT2 exhibit a complementary expression pattern covering all glutamatergic pathways in the CNS, expression of hVGLUT3 overlaps with them in some brain areas, suggesting molecular diversity that may account for physiological heterogeneity in glutamatergic synapses.

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Language(s): eng - English
 Dates: 2002-08
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: EMBO Reports
Source Genre: Journal
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Pages: - Volume / Issue: 3 (8) Sequence Number: - Start / End Page: 798 - 803 Identifier: -