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  Synaptic plasticity and tianeptine: structural regulation

Fuchs, E., Czeh, B., Michaelis, T., de Biurrun, G., Watanabe, T., & Frahm, J. (2002). Synaptic plasticity and tianeptine: structural regulation. European Psychiatry, 17(Suppl. 3), 311S-317S. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VM1-47C71PD-5-5&_cdi=6137&_user=38661&_pii=S0924933802006521&_origin=search&_coverDate=07%2F31%2F2002&_sk=999829999.8996&view=c&wchp=dGLbVlz-zSkWA&md5=57ab2e04aee420924d2338d884d697de&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F385-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E559-9
Genre: Journal Article

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16654.pdf (Publisher version), 0B
 
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 Creators:
Fuchs, E., Author
Czeh, B., Author
Michaelis, T.1, Author
de Biurrun, G., Author
Watanabe, T.2, Author              
Frahm, J.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: depression; hippocampus; stress; tianeptine
 Abstract: Stress-induced structural and cellular alterations in the hippocampus can contribute to the pathophysiology of depression, The reversal of these alterations may be a mechanism by which antidepressants achieve their therapeutic effect. The aim of the present study was therefore to investigate the effect of tianeptine on stress-induced structural changes and alterations in cerebral metabolites. To this end, psychosocially stressed male tree shrews were treated with tianeptine. A combination of in vivo and postmortem methods was used to evaluate the antidepressant treatment on the preservation of neuronal plasticity. It was found that all stress-induced effects were prevented by the administration of tianeptine. It is concluded that these findings provide experimental evidence for recent theories that impairment of neuronal viability and neuroplasticity might be important causal factors in mood disorders, suggesting tianeptine as a potential stimulator of neural resilience. (C) 2002 Editions scientifiques et medicales Elsevier SAS.

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Language(s): eng - English
 Dates: 2002-07
 Publication Status: Published in print
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 Rev. Type: Peer
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Title: European Psychiatry
Source Genre: Journal
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Pages: - Volume / Issue: 17 (Suppl. 3) Sequence Number: - Start / End Page: 311S - 317S Identifier: -