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  Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells

Wolf, C., Gerlach, N., & Schuh, R. (2002). Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells. EMBO Reports, 3(6), 563-568. Retrieved from http://www.nature.com/embor/journal/v3/n6/pdf/embor143.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F39C-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E56E-C
Genre: Journal Article

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15607.pdf (Publisher version), 0B
 
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 Creators:
Wolf, C.1, Author              
Gerlach, N.2, Author              
Schuh, R.2, Author              
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
2Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society, ou_578591              

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 Abstract: Development of the ectodermally derived Drosophila tracheal system is based on branch outgrowth and fusion that interconnect metamerically arranged tracheal subunits into a highly stereotyped three-dimensional tubular structure. Recent studies have revealed that this process involves a specialized cell type of mesodermal origin, termed bridge-cell. Single bridge-cells are located between adjacent tracheal subunits and serve as guiding posts for the outgrowing dorsal trunk branches. We show that bridge-cell-approaching tracheal cells form filopodia-like cell extensions, which attach to the bridge-cell surface and are essential for the tracheal subunit interconnection. The results of both dominant-negative and gain-of-function experiments suggest that the formation of cell extensions require Cdc42-mediated Drosophila fibroblast growth factor activity.

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Language(s): eng - English
 Dates: 2002-06
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: EMBO Reports
Source Genre: Journal
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Pages: - Volume / Issue: 3 (6) Sequence Number: - Start / End Page: 563 - 568 Identifier: -