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  Rotatin is a novel gene required for axial rotation and left- right specification in mouse embryos

Faisst, A. M., Alvarez-Bolado, G., Treichel, D., & Gruss, P. (2002). Rotatin is a novel gene required for axial rotation and left- right specification in mouse embryos. Mechanisms of Development, 113(1), 15-28. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9H-454HKFP-2-H&_cdi=5115&_user=38661&_pii=S0925477302000035&_origin=search&_coverDate=04%2F30%2F2002&_sk=998869998&view=c&wchp=dGLbVtz-zSkzV&md5=e45ee87bd5c72d8108b79eb90b72439d&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F406-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0EDC-E
Genre: Journal Article

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 Creators:
Faisst, A. M., Author
Alvarez-Bolado, G.1, Author              
Treichel, D.2, Author              
Gruss, P.2, Author              
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              
2Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

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Free keywords: axial rotation; mouse; gene trap; beta-galactosidase reporter; left-right development; nodal; lefty-2; Pitx2
 Abstract: The genetic cascade that governs left-right (L-R) specification is starting to be elucidated. In the mouse, the lateral asymmetry of the body axis is revealed first by the asymmetric expression of nodal, lefry2 and pitx2 in the left lateral plate mesoderm of the neurulating embryo. Here we describe a novel gene, rotatin, essential for the correct expression of the key L-R specification genes nodal, lefty and Pitx2. Embryos deficient in rotatin show also randomized heart looping and delayed neural tube closure, and fail to undergo the critical morphogenetic step of axial rotation. The amino acid sequence deduced from the cDNA is predicted to contain at least three transmembrane domains. Our results show a novel key player in the genetic cascade that determines L-R specification, and suggest a causal link between this process and axial rotation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2002-04
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Mechanisms of Development
Source Genre: Journal
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Pages: - Volume / Issue: 113 (1) Sequence Number: - Start / End Page: 15 - 28 Identifier: -