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  Vesicle pools and short-term synaptic depression: lessons from a large synapse

Schneggenburger, R., Sakaba, T., & Neher, E. (2002). Vesicle pools and short-term synaptic depression: lessons from a large synapse. Trends in Neurosciences, 25(4), 206-212. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0V-46039BN-D-8&_cdi=4872&_user=38661&_pii=S0166223602021392&_origin=search&_coverDate=04%2F01%2F2002&_sk=999749995&view=c&wchp=dGLbVzz-zSkzV&md5=48e274446f18c6fa3172f11d95557600&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F40B-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-279C-F
Genre: Journal Article

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Schneggenburger, R.1, Author              
Sakaba, T.2, Author              
Neher, E.3, Author              
Affiliations:
1Research Group of Synaptic Dynamics and Modulation, MPI for Biophysical Chemistry, Max Planck Society, ou_578582              
2Research Group of Biophysics of Synaptic Transmission, MPI for biophysical chemistry, Max Planck Society, ou_578583              
3Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Depletion of a pool of readily releasable vesicles during repetitive presynaptic activity is a candidate mechanism for the induction of short-term synaptic depression. The large, calyx-type synaptic terminals in the brainstem auditory pathway, and especially the calyx of Held, offer unique possibilities for studying the cellular mechanisms leading to synaptic depression. Recent Work at these synapses using presynaptic whole-cell patch-clamp recordings has revealed a large pool of readily releasable vesicles. During prolonged presynaptic depolarization, vesicles are released in kinetically distinct phases, indicating heterogeneity of release probability between vesicles. Heterogeneity might endow synapses with a rapid phase of depression at the onset of activity, followed by sustained and surprisingly large synaptic strength during the steady-state phase of depression. By influencing the synaptic output during repetitive activity, vesicle pool dynamics are expected to modulate information processing in neuronal networks of the CNS.

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Language(s): eng - English
 Dates: 2002-04
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Trends in Neurosciences
Source Genre: Journal
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Pages: - Volume / Issue: 25 (4) Sequence Number: - Start / End Page: 206 - 212 Identifier: -