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  Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion

Antonin, W., Wagner, M., Riedel, D., Brose, N., & Jahn, R. (2002). Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Molecular and Cellular Biology, 22(5), 1545-1554. Retrieved from http://mcb.asm.org/cgi/reprint/22/5/1545.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F42C-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-BC99-B
Genre: Journal Article

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Antonin, W.1, Author              
Wagner, M.2, Author              
Riedel, D.3, Author              
Brose, N., Author
Jahn, R.1, Author              
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              
2Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              
3Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              

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 Abstract: Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane. To shed light on the hitherto unknown function of syncollin, we have generated syncollin-deficient mice. The mice are viable and show a normal pancreatic morphology as well as normal release kinetics in response to secretagogue stimulation. Although syncollin is highly enriched in zymogen granules, no change was found in the overall protein content and in the levels of chymotrypsin, trypsin, and amylase. However, syncollin-deficient mice reacted to caerulein hyper-stimulation with a more severe pancreatitis. Furthermore, the rates of both protein synthesis and intracellular transport of secretory proteins were reduced. We conclude that syncollin plays a role in maturation and/or concentration of zymogens in zymogen granules.

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Language(s): eng - English
 Dates: 2002-03
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Molecular and Cellular Biology
Source Genre: Journal
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Pages: - Volume / Issue: 22 (5) Sequence Number: - Start / End Page: 1545 - 1554 Identifier: -