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  Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

Antonin, W., Fasshauer, D., Becker, S., Jahn, R., & Schneider, T. R. (2002). Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nature Structural Biology, 9(2), 107-111. Retrieved from http://www.nature.com/nsmb/journal/v9/n2/pdf/nsb746.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F459-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8F99-F
Genre: Journal Article

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Antonin, W.1, Author              
Fasshauer, D.2, Author              
Becker, S.3, Author              
Jahn, R.1, Author              
Schneider, T. R., Author
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1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              
2Research Group of Structural Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578596              
3Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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 Abstract: SNARE proteins are crucial for intracellular membrane fusion in all eukaryotes. These proteins assemble into tight complexes that connect membranes and may induce fusion. The crystal structure of the neuronal core complex is represented by an unusually long bundle of four alpha-helices connected by 16 layers of mostly hydrophobic amino acids. Here we report the 1.9 Angstrom resolution crystal structure of an endosomal SNARE core complex containing four SNAREs: syntaxin 7, syntaxin 8, vti1b and endobrevin/VAMP-8. Despite limited sequence homology, the helix alignment and the layer structure of the endosomal complex are remarkably similar to those of the neuronal complex. However, subtle variations are evident that characterize different SNARE subfamilies. We conclude that the structure of the SNARE core complex is an evolutionarily conserved hallmark of all SNARE complexes and is intimately associated with the general role of SNAREs in membrane fusion.

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Language(s): eng - English
 Dates: 2002-02
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Nature Structural Biology
Source Genre: Journal
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Pages: - Volume / Issue: 9 (2) Sequence Number: - Start / End Page: 107 - 111 Identifier: -