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  Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N., & Rhee, J. S. (2002). Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron, 33(3), 411-424. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSS-4537XK5-C-N&_cdi=7054&_user=38661&_pii=S0896627302005688&_origin=search&_coverDate=01%2F31%2F2002&_sk=999669996&view=c&wchp=dGLbVtb-zSkWA&md5=e17eecf9269c23f585ba11ab3f51330e&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F464-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-D654-8
Genre: Journal Article

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599710.pdf (Publisher version), 544KB
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Rosenmund, C.1, Author              
Sigler, A.1, Author              
Augustin, I., Author
Reim, K., Author
Brose, N., Author
Rhee, J. S.1, Author              
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1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Presynaptic short-term plasticity is an important adaptive mechanism regulating synaptic transmitter release at varying action potential frequencies. However, the underlying molecular mechanisms are unknown. We examined genetically defined and functionally unique axonal subpopulations of synapses in excitatory hippocampal neurons that utilize either Munc13-1 or Munc13-2 as synaptic vesicle priming factor. In contrast to Munc13-1-dependent synapses, Munc-13-2-driven synapses show pronounced and transient augmentation of synaptic amplitudes following high-frequency stimulation. This augmentation is caused by a Ca2+-dependent increase in release probability and releasable vesicle pool size, and requires phospholipase C activity. Thus, differential expression of Munc13 isoforms at individual synapses represents a general mechanism that controls short-term plasticity and contributes to the heterogeneity of synaptic Information coding.

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Language(s): eng - English
 Dates: 2002-01-31
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 33 (3) Sequence Number: - Start / End Page: 411 - 424 Identifier: -