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  Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TR alpha gene

Flamant, F., Poguet, A. L., Plateroti, M., Chassande, O., Gauthier, K., Streichenberger, N., et al. (2002). Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TR alpha gene. Molecular Endocrinology, 16(1), 24-32. Retrieved from http://mend.endojournals.org/cgi/reprint/16/1/24.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F47C-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E59C-2
Genre: Journal Article

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 Creators:
Flamant, F., Author
Poguet, A. L., Author
Plateroti, M., Author
Chassande, O., Author
Gauthier, K., Author
Streichenberger, N., Author
Mansouri, A.1, Author              
Samarut, J., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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 Abstract: Mice devoid of all TRs are viable, whereas Pax8(-/-)mice, which lack the follicular cells producing T-4 and T-3 in the thyroid gland, die during the first weeks of postnatal life. A precise comparison between the two types of mutants reveals that their phenotypes are similar, but the defects in spleen, bone, and small intestine are more pronounced in Pax(-/-) mice. This is interpreted as the result of a negative effect of the unliganded TR on thyroid hormone target genes expression in the Pax(-/-)mutants. Pax8(-/-) compound mutants can survive to adulthood, and the expression of target genes is partially restored. This demonstrates the importance of TR alpha aporeceptor activity in several aspects of postnatal development.

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Molecular Endocrinology
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 16 (1) Sequence Number: - Start / End Page: 24 - 32 Identifier: -