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  Mapping and identification of essential gene functions on the X chromosome of Drosophila

Peter, A., Schoettler, P., Werner, M., Beinert, N., Dowe, G., Burkert, P., et al. (2002). Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Reports, 3(1), 34-38. Retrieved from http://www.nature.com/embor/journal/v3/n1/pdf/embor247.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F480-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E570-4
Genre: Journal Article

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 Creators:
Peter, A.1, Author              
Schoettler, P.1, Author              
Werner, M.1, Author              
Beinert, N., Author
Dowe, G.1, Author              
Burkert, P.1, Author              
Mourkioti, F., Author
Dentzer, L., Author
He, Y. C., Author
Deak, P., Author
Benos, P. V., Author
Gatt, M. K., Author
Murphy, L., Author
Harris, D., Author
Barrell, B., Author
Ferraz, C., Author
Vidal, S., Author
Brun, C., Author
Demailles, J., Author
Cadieu, E., Author
Dreano, S., AuthorGloux, S., AuthorLelaure, V., AuthorMottier, S., AuthorGalibert, F., AuthorBorkova, D., AuthorMinana, B., AuthorKafatos, F. C., AuthorBolshakov, S., AuthorSiden-Kiamos, I., AuthorPapagiannakis, G., AuthorSpanos, L., AuthorLouis, C., AuthorMadueno, E., Authorde Pablos, B., AuthorModolell, J., AuthorBucheton, A., AuthorCallister, D., AuthorCampbell, L., AuthorHenderson, N. S., AuthorMcMillan, P. J., AuthorSalles, C., AuthorTait, E., AuthorValenti, P., AuthorSaunders, R. D. C., AuthorBillaud, A., AuthorPachter, L., AuthorKlapper, R., AuthorJanning, W., AuthorGlover, D. M., AuthorAshburner, M., AuthorBellen, H. J., AuthorJaeckle, H.1, Author              Schaefer, U.1, Author               more..
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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 Abstract: The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics Systems, have sequenced the genome, complementing the previously established physical and genetic maps. In addition, the Berkeley Drosophila Genome Project has undertaken large-scale functional analysis based on mutagenesis by transposable P element insertions into autosomes. Here, we present a large-scale P element insertion screen for vital gene functions and a BAC tiling map for the X chromosome. A collection of 501 X-chromosomal P element insertion lines was used to map essential genes cytogenetically and to establish short sequence tags (STSs) linking the insertion sites to the genome. The distribution of the P element integration sites, the identified genes and transcription units as well as the expression patterns of the P-element-tagged enhancers is described and discussed.

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: EMBO Reports
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 3 (1) Sequence Number: - Start / End Page: 34 - 38 Identifier: -