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  Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K+ channel subunit, TASK-5, associated with the central auditory nervous system

Karschin, C., Wischmeyer, E., Preisig-Mueller, R., Rajan, S., Derst, C., Grzeschik, K. H., et al. (2001). Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K+ channel subunit, TASK-5, associated with the central auditory nervous system. Molecular and Cellular Neuroscience, 18(6), 632-648. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WNB-456JPMM-5-1&_cdi=6958&_user=38661&_pii=S1044743101910450&_origin=search&_coverDate=12%2F31%2F2001&_sk=999819993&view=c&wchp=dGLbVtz-zSkzk&md5=b9a83a8cbe4d1cf29341b4ca00718c3a&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F51C-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-E33E-6
Genre: Journal Article

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233178.pdf (Publisher version), 0B
 
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Karschin, C.1, Author              
Wischmeyer, E.1, Author              
Preisig-Mueller, R., Author
Rajan, S., Author
Derst, C., Author
Grzeschik, K. H., Author
Daut, J., Author
Karschin, A.1, Author              
Affiliations:
1Research Group of Molecular Neurobiology of Signal Transduction, MPI for biophysical chemistry, Max Planck Society, ou_578561              

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 Abstract: TWIK-related acid-sensitive K+ (TASK) channels contribute to setting the resting potential of mammalian neurons and have recently been defined as molecular targets for extracellular protons and volatile anesthetics. We have isolated a novel member of this subfamily, hTASK-5, from a human genomic library and mapped it to chromosomal region 20q12-20q13. hTASK-5 did not functionally express in Xenopus oocytes, whereas chimeric TASK-5/TASK-3 constructs containing the region between M1 and M3 of TASK-3 produced K+ selective currents. To better correlate TASK subunits with native K+ currents in neurons the precise cellular distribution of all TASK family members was elucidated in rat brain. A comprehensive in situ hybridization analysis revealed that both TASK-1 and TASK-3 transcripts are most strongly expressed in many neurons likely to be cholinergic, serotonergic, or noradrenergic. In contrast, TASK- 5 expression is found in olfactory bulb mitral cells and Purkinje cells, but predominantly associated with the central auditory pathway. Thus, TASK-5 K+ channels, possibly in conjunction with auxiliary proteins, may play a role in the transmission of temporal information in the auditory system.

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Language(s): eng - English
 Dates: 2001-12
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Molecular and Cellular Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 18 (6) Sequence Number: - Start / End Page: 632 - 648 Identifier: -